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TrkB Antibody

based on 3 citations in multiple journalsTrkB Antibody34.1 4
Catalog #: 3593
SKU-Size Size Price Qty
3593-30T 30 µg
$89.00
3593-100 100 µg
$310.00
More Sizes Get Quote

Product Details

Antibody Target TrkB
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 810 of human TrkB
Accession # Q63604
Gene ID 25054
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation In phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin.
Purification Affinity purified
Species Reactivity Human, mouse, rat, chicken
Application Western blot, Immunoprecipitation, Immunofluorescence
Application & Usage Western blotting (0.5-4 µg/ml), immunofluorescence (5-10 µg/ml). However, the optimal concentrations should be determined individually. Trk protein exists as variably glycosylated entities with the major forms having molecular weights of 140 kDa, 110 kDa,
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. trkB contains 33.3% carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting throμgh trkB such as BDNF.


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Shen, J. et al., N-acetyl serotonin derivatives as potent neuroprotectants for retinas,  PNAS, Feb 2012; 109: 3540 - 3545.
Jang, S. et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone PNAS, Feb 2010; 107: 2687 - 2692.
Jang, S. et. al. N-acetylserotonin activates TrkB receptor in a circadian rhythm PNAS, Feb 2010; 107: 3876 - 3881.
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