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Triptolide

based on 1 citations in multiple journalsTriptolide14.1 4
A NF-kappaB inhibitor
Catalog #: 1761
SKU-Size Size Price Qty
1761-1 1 mg
$70.00
1761-5 5 mg
$275.00
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Product Details

Alternate Name TPL
Appearance Off-white solid
CAS # 38748-32-2
Molecular Formula C₂₀H₂₄O₆
Molecular Weight 360.4
Purity ≥97% by HPLC
Solubility DMSO (20 mg/ml)
SMILES CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C
InChi InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1
InChi Key DFBIRQPKNDILPW-CIVMWXNOSA-N
PubChem CID 107985
MDL Number MFCD00210565
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Triptolide, a diterpenoid triepoxyde, a purified component of a traditional Chinese medicine, inhibits transcriptional activation of NF- κB and downregulates the expression of various NF- κB-regulated genes. Displays Immunosuppressive, anti-inflammatory, anti-angiogenic and antitumor activity. A combination of TRAIL and triptolide enhance apoptosis in cholangiocarcinoma cell lines.


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Claudia Villicaña et al., The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila. J. Cell Sci., Jun 2013; 126: 2502 - 2515.
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