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Product Details
| Alternate Name | G1T28 dihydrochloride; 4-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]spiro[1,3,5,11-tetrazatricyclo[7.4.0.02,7]trideca-2,4,6,8-tetraene-13,1'-cyclohexane]-10-one;dihydrochloride |
|---|---|
| Appearance | Solid |
| CAS # | 1977495-97-8 |
| Molecular Formula | C₂₄H₃₂Cl₂N₈O |
| Molecular Weight | 519.5 |
| Purity | ≥ 97% |
| SMILES | CN1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C=C5C(=O)NCC6(N5C4=N3)CCCCC6.Cl.Cl |
| InChi | InChI=1S/C24H30N8O.2ClH/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23;;/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29);2*1H |
| InChi Key | BRCYOXKEDFAUSA-UHFFFAOYSA-N |
| PubChem CID | 124081865 |
| MDL Number | MFCD31630829 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Trilaciclib dihydrochloride is a CDK4/6 inhibitor which reduces chemotherapy-induced myelosuppression. It induces a G1 cell-cycle arrest in CDK4/6-dependent HS68 cells with an EC₅₀ of 30 nM. It is used to reduce the frequency of chemotherapy-induced bone marrow suppression in adults receiving certain types of chemotherapy.
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