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Trigonelline Chloride

An anti-diabetic agent
Catalog #: B2606
SKU-Size Size Price Qty
B2606-100 100 mg
B2606-500 500 mg
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Product Details

Alternate Name 3-carboxy-1-methyl-pyridinium, monochloride, N-methyl Nicotinic Acid betaine
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 6138-41-6
Molecular Formula C₇H₈NO₂ • Cl
Molecular Weight 173.6
Purity ≥98% by HPLC
Solubility ~ 5 mg/ml in DMSO
SMILES OC(C1=C[N+](C)=CC=C1)=O.[Cl-]
InChi InChI=1S/C7H7NO2.ClH/c1-8-4-2-3-6(5-8)7(9)10;/h2-5H,1H3;1H
PubChem CID 134606
MDL Number MFCD00077250
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Trigonelline is a pyridine alkaloid found in various edible seeds and legumes, including coffee. It is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3; nicotinic acid) and, as a product of niacin metabolism, is excreted in urine of mammals. Trigonelline has been used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes. Trigonelline protects diabetic pregnancy partly by suppressing inflammation, regulating the secretion of adipocytokines, increasing β-cell mass, replication, and decreasing β-cell apoptosis.

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