Product Details
| Cat # +Size | 1606-1 |
|---|---|
| Size | 1 mg |
| Alternate Name | TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide |
| Appearance | White solid |
| CAS # | 58880-19-6 |
| Molecular Formula | C₁₇H₂₂N₂O₃ |
| Molecular Weight | 302.4 |
| Purity | ≥99% |
| Solubility | DMSO (20 mg/ml) or EtOH (2 mg/ml) |
| SMILES | CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
| InChi | InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 |
| InChi Key | RTKIYFITIVXBLE-QEQCGCAPSA-N |
| PubChem CID | 444732 |
| MDL Number | MFCD03848392 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Potent, reversible inhibitor of histone deacetylase. Mediates the activation of O6- methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types, induces cell growth arrest at both G1 and G2/M phases. In some cases induces apoptosis.
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Chen, S. et. al. Histone Deacetylase (HDAC) Activity Is Critical for Embryonic Kidney Gene Expression, Growth, and Differentiation. J. Biol. Chem., Sep 2011; 286: 32775 - 32789.
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