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Trichostatin A

based on 1 citations in multiple journalsTrichostatin A14.1 4
A HDAC inhibitor
Catalog #: 1606
$145.00

Product Details

Cat # +Size 1606-1
Size 1 mg
Alternate Name TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Appearance White solid
CAS # 58880-19-6
Molecular Formula C₁₇H₂₂N₂O₃
Molecular Weight 302.4
Purity ≥99%
Solubility DMSO (20 mg/ml) or EtOH (2 mg/ml)
SMILES CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
InChi InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
InChi Key RTKIYFITIVXBLE-QEQCGCAPSA-N
PubChem CID 444732
MDL Number MFCD03848392
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Potent, reversible inhibitor of histone deacetylase. Mediates the activation of O6- methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types, induces cell growth arrest at both G1 and G2/M phases. In some cases induces apoptosis.


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Chen, S. et. al. Histone Deacetylase (HDAC) Activity Is Critical for Embryonic Kidney Gene Expression, Growth, and Differentiation. J. Biol. Chem., Sep 2011; 286: 32775 - 32789.
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