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TREM2, human recombinant

Involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines
Catalog #: 7357
$295.00

Product Details

Cat # +Size 7357-50
Size 50 μg
Alternate Name Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c
Gene Symbol TREM2
Gene ID 54209
Accession # Q9NZC2
Source E. coli
Appearance Liquid
Physical Form Description 0.25 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 10% glycerol.
Molecular Weight 20.4 kDa (181 aa, 19-161 aa + His Tag), confirmed by MALDI-TOF.
Purity by SDS-PAGE ≥90%
Amino Acid Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS R
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

TREM2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.


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