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TREM2 (Human) ELISA Kit

A Sandwich ELISA kit for quantitative measurement of TREM2 in human serum, plasma, tissue lysates, and other biological fluids
Catalog #: E4973
$795.00

Product Details

Cat # +Size E4973-100
Size 96 assays
Detection Method Absorbance (450 nm)
Species Reactivity Human
Applications Sandwich ELISA kit to quantitatively measure TREM2 in human serum, plasma, tissue lysate, and other biological fluids
Features & Benefits ● This Sandwich ELISA is highly sensitive and highly specific for the detection of TREM2 in human samples. There is no significant cross-reactivity or interference between TREM2 and analogues
● Assay Precision: Intra-Assay CV < 8% and Inter-Assay CV < 10%
● Sensitivity: 46.875 pg/ml
● Recovery range: 85 - 105% for normal human serum and plasma samples
● Detection range: 78.125 – 5000 pg/ml
Kit Components ● Micro ELISA plate
● Wash Buffer (25X)
● Plate Sealers
● Standard (Lyophilized) (5000 pg)
● Sample/Standard Dilution Buffer
● Biotin-labeled Antibody
● Antibody Dilution Buffer
● HRP-Streptavidin Conjugate (SABC)
● SABC Dilution Buffer
● TMB Substrate Solution
● Stop Solution
Storage Conditions 4ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass cell surface transmembrane glycoprotein that belongs to the superfamily of immunoglobulins. It is expressed in macrophages, dendritic cells, myeloid cells, and osteoclasts. TREM2 binds to ligands such as bacterial LPS and DNA, phospholipids, and sulfatides. TREM2 also binds to transmembrane adaptor proteins such as DNAX-activation protein 12 (DAP12) and induces phagocytosis of pathogens and cell debris. TREM2 acts as an anti-inflammatory molecule and decreases the expression and secretion of pro-inflammatory cytokines such as TNFα and IL-6. TREM2 also regulates the cell number, proliferation, and survival of myeloid cells. Mutations in TREM2 result in diseases such as dementia, Alzheimer’s disease, ALS, Parkinson’s disease, and Nasu-Hakola disease. BioVision’s TREM2 (Human) ELISA kit is based on the Sandwich principle to quantitatively measure the concentration of TREM2 in human serum, plasma, and other biological fluids. Test samples, Standards, and Biotinylated Detection antibody are added to the wells pre-coated with capture antibody and then washed with Wash Buffer. The HRP-Streptavidin is added and any unattached conjugates are washed off by Wash Buffer. The HRP enzymatic reaction is detected by the addition of TMB-substrate. Finally, the reaction is terminated with an acidic stop solution. The color developed is directly proportional to the concentration of TREM2 in the sample or standard.


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