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Traut's Reagent

A useful reagent for converting primary amine functional groups into free sulfhydryl groups
Catalog #: 2330
SKU-Size Size Price Qty
2330-500 500 mg
2330-1000 1 g
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Product Details

Alternate Name 2-Iminothiolane HCl; 2-IT; Dihydro-2-(3H)-thiophenimine hydrochloride; Dihydro-2-(3H)-thiophenimine HCl
Appearance White solid
CAS # 4781-83-3
Molecular Formula C₄H₇NS•HCl
Molecular Weight 137.63
Purity ≥90% by NMR
Solubility H2O or aqueous buffers
InChi InChI=1S/C4H7NS.ClH/c5-4-2-1-3-6-4;/h5H,1-3H2;1H
PubChem CID 13166855
MDL Number MFCD00039013
Handling Protect from moisture
Storage Conditions 4 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


KEY FEATURES & APPLICATIONS:• Water-soluble• Adds a 5-atom spacer arm (8.1 Å) to minimize steric hindrance• The spacer is cleavable at the disulfide bond with reducing agent, such as DTT, TCEP, etc.• Commonly used to convert primary amines into sulfhydryl groups in a one-step process is called thiolation• Amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides• Useful RNA-protein crosslinking reagent.

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