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Trabectedin

An antitumor agent
Catalog #: B3084
SKU-Size Size Price Qty
B3084-250 250 μg
$345.00
B3084-1000 1 mg
$1,095.00
More Sizes Get Quote

Product Details

Alternate Name Ecteinascidin; [(1R,2R,3R,11S,12S,14R,26R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-
oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-
4(9),5,7,15,20,22-hexaene-26,1'-3,4-dihydro-2H-isoquinoline]-22-yl] acetate; ecteinascidin 743; ET-743
Appearance White to off-white powder
CAS # 114899-77-3
Molecular Formula C₃₉H₄₃N₃O₁₁S
Molecular Weight 761.84
Purity ≥ 98%
Solubility Soluble in DMSO
SMILES CC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)O)COC(=O)C8(CS5)C9=CC(=C(C=C9CCN8)
O)OC)OCO7)C)OC(=O)C)C(=C1OC)O
InChi InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1
InChi Key PKVRCIRHQMSYJX-AIFWHQITSA-N
PubChem CID 108150
MDL Number MFCD00874849
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Trabectedin is a natural product originally isolated from the sea squirt, Ecteinascidia turbinata and is currently prepared synthetically. It interferes with transcription factors, DNA‐binding proteins, DNA repair pathways and shows potent antitumor activity. It suppresses the proliferation of Clear cell sarcoma cell lines with IC₅₀ values ranging from 0.30 nM-0.50 nM. It is approved for the treatment of unresectable or metastatic liposarcoma or leiomyosarcoma who received prior chemotherapy with an anthracycline.


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