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TPO, rat recombinant

Stimulates the proliferation and maturation of megakaryocytes
Catalog #: 7221
SKU-Size Size Price Qty
7221-10 10 μg
$185.00
7221-50 50 μg
$825.00
More Sizes Get Quote

Product Details

Alternate Name Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF
Gene Symbol TPO
Gene ID 81811
Accession # P49745
Source E. Coli
Appearance Lyophilized powder
Physical Form Description Sterile filtered through a 0.2 micron filter. Lyophilized from Sodium Citrate, pH 4.5
Molecular Weight 18.7 kDa
Purity by SDS-PAGE ≥98%
Endotoxin Level < 0.1 ng/μg of protein (<1EU/μg).
Biological Activity Determined by its ability to stimulate the proliferation of human MO7e cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carri
Amino Acid Sequence SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRGKVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKF
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.


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