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TPO, human recombinant

based on 1 citations in multiple journalsTPO, human recombinant14.1 4
Stimulates the proliferation and maturation of megakaryocytes
Catalog #: 4351
SKU-Size Size Price Qty
4351-10 10 μg
$180.00
4351-50 50 μg
$495.00
4351-1000 1 mg
$3,900.00
More Sizes Get Quote

Product Details

Alternate Name Megakaryocyte colony-stimulating factor, Myeloproliferative leukemia virus oncogene ligand, C-mpl ligand, ML, Megakaryocyte growth and development factor, MGDF, TPO, MKCSF, MPLLG, MGC163194, THPO.
Gene Symbol TPO
Accession # P40225
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized with no additives
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found <1 ng/ml, corresponding to a specific activity of >1 x 10⁶ IU/mg.
Reconstitution Instructions Reconstitution in purified H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. For long term storage it is recommended to add a carrier protein (0.1%
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide, which contains the erythropoietin-like domain of the full length TPO protein.


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Kinzfogl, J. et. al. Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. Blood, Jul 2011; 118: 565 - 575.
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