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TPA, Human Recombinant

tPA is a serine protease enzyme that converts plasminogen to plasmin.
Catalog #: P1324

In stock

SKU-Size Size Price Qty
P1324-20 20 µg
P1324-100 100 µg
P1324-1000 1 mg
More Sizes Get Quote

Product Details

Alternate Name Tissue-type plasminogen activator, EC, tPA, t-PA, t-plasminogen activator, TPA, T-PA, DKFZp686I03148.
Gene Symbol PLAT
Accession # P00750
Source Chinese Hamster Ovary Cells (CHO)
Appearance Sterile Filtered White lyophilized (freeze-dried) powder
Physical Form Description Each mg of t-PA contains 1.7 g L-arginine, 0.5 g phosphoric acid and 4 mg tween 80.
Molecular Weight 59 kDa
Purity by SDS-PAGE ≥ 98.0%
Reconstitution Instructions It is recommended to reconstitute the lyophilized t-PA in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Tissue plasminogen activator (PLAT or tPA) is a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Tissue Plasminogen Activator Human Recombinant produced in CHO cells is a single, glycosylated polypeptide chain containing 527 amino acids and having a molecular mass of 59 kDa. tPA is a serine protease enzyme that converts plasminogen to plasmin. The tPA is purified by proprietary chromatographic techniques.

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