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TPA (36-310), Human Recombinant

Plays a role in cell migration and tissue remodeling.
Catalog #: P1323

In stock

SKU-Size Size Price Qty
P1323-5 5 µg
$295.00
P1323-50 50 µg
$1,995.00
More Sizes Get Quote

Product Details

Alternate Name Tissue-type plasminogen activator, EC 3.4.21.68, tPA, t-PA, t-plasminogen activator, TPA, T-PA, DKFZp686I03148, PLAT and tPA, Alteplase, Reteplase, Plasminogen Activator, Tissue, Plasminogen/Activator Kringle.
Gene Symbol PLAT
Accession # P00750
Source Sf9, Baculovirus cells
Appearance Sterile Filtered colorless solution
Physical Form Description TPA protein solution (0.25mg/ml) contains 50mM MES(pH5.5),10% glycerol, 100mM NaCl and 5mM CaCl2.
Molecular Weight 32.0 kDa
Purity by SDS-PAGE ≥ 90%
Reconstitution Instructions Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time and for long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Amino Acid Sequence ADPSYQVICR DEKTQMIYQQ HQSWLRPVLR SNRVEYCWCN SGRAQCHSVP VKSCSEPRCF NGGTCQQALY FSDFVCQCPE GFAGKCCEID TRATCYEDQG ISYRGTWSTA ESGAECTNWN SSALAQKPYS GRRPDAIRLG LGNHNYCRNP DRDSKPWCYV FKAGKYSSEF CSTPACSEGN SDCYFGNGSA YRGTHSLTES GASCLPWNSM ILIGKVYTAQ NPSAQALGLG KH
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Tissue plasminogen activator (PLAT or tPA) is a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Plasminogen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. TPA Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 284 amino acids (36-310 a.a.) and having a molecular mass of 32.0 kDa (Molecular size on SDS-PAGE will appear at approximately 28-40 kDa). TPA is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.


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