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A potent and selective AXL kinase Inhibitor
Catalog #: 9590
SKU-Size Size Price Qty
9590-5 5 mg
9590-25 25 mg
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Product Details

Alternate Name 2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide; Dubermatinib
Appearance White solid
CAS # 1341200-45-0
Molecular Formula C₂₄H₃₀ClN₇O₂S
Molecular Weight 516.06
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
InChi InChI=1S/C24H30ClN7O2S/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32/h4-11,16H,12-15,17H2,1-3H3,(H2,26,27,28,29)
PubChem CID 56839178
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


TP-0903 is a potent and selective AXL Inhibitor (IC₅₀ = 27 nM). TP-0903 induces massive apoptosis in CLL B cells with LD₅₀ values of nanomolar ranges. Treatment of cancer cells with TP-0903 reverses the mesenchymal phenotype in multiple models and sensitizes cancer cells to treatment with other targeted agents.

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