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Tozasertib (VX-680, MK-0457, VX6)

based on 1 citations in multiple journalsTozasertib (VX-680, MK-0457, VX6)14.1 4
An Aurora kinase inhibitor
Catalog #: 1595
SKU-Size Size Price Qty
1595-25 25 mg
1595-100 100 mg
More Sizes Get Quote

Product Details

Alternate Name MK-0457, VX6, VX-680
Appearance White to off-white solid
CAS # 639089-54-6
Molecular Formula C₂₃H₂₈N₈OS
Molecular Weight 464.59
Purity ≥99% by HPLC
Solubility DMSO (100 mg/ml)
InChi InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
PubChem CID 5494449
MDL Number MFCD10565966
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Tozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms.

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Derek S. Welsbie et al., Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. PNAS, Mar 2013; 110: 4045 - 4050.
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