Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Tozasertib (VX-680, MK-0457, VX6)

based on 1 citations in multiple journalsTozasertib (VX-680, MK-0457, VX6)14.1 4
An Aurora kinase inhibitor
Catalog #: 1595

In stock

SKU-Size Size Price Qty
1595-25 25 mg
$100.00
1595-100 100 mg
$310.00
More Sizes Get Quote

Product Details

Alternate Name MK-0457, VX6, VX-680
Appearance White to off-white solid
CAS # 639089-54-6
Molecular Formula C₂₃H₂₈N₈OS
Molecular Weight 464.59
Purity ≥99% by HPLC
Solubility DMSO (100 mg/ml)
SMILES CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
InChi InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
InChi Key GCIKSSRWRFVXBI-UHFFFAOYSA-N
PubChem CID 5494449
MDL Number MFCD10565966
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Tozasertib inhibits Aurora kinases A, B and C with Ki values of 0.6, 18 and 4.6 nM, respectively. It also inhibits Flt-3 and Abl as well as their mutant forms.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.
Derek S. Welsbie et al., Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. PNAS, Mar 2013; 110: 4045 - 4050.
For more citations of this product click here