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ToxOut™ Endotoxin Rapid Removal Agarose

5 ml settled resin that can quickly and effectively eliminate endotoxins to < 0.05 EU/ml in solutions.
Catalog #: 7941

Product Details

Cat # +Size 7941-5
Size 5 ml
Highlights • High Binding Capacity: up to 9 x 108 EU/ml resin.
• High Sample Recovery: ~90% recovery with protein solution samples.
• Resin Content: affinity matrix of polymyxin B, supplied as 50% slurry in 20% ethanol.
• ToxOutTM Rapid Endotoxin Removal Agarose can be reused up to 5 times.
Storage Conditions 4°C. Do not freeze.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Endotoxin is the lipopolysaccharide (LPS) complex located in the outer membrane of gram-negative bacteria. A single E.coli bacterium contains ~2 million LPS molecules (2 – 20 fg/cell). During experimental procedures, large amount of endotoxins are shed and can easily contaminate labware, buffers and downstream products. In vitro, endotoxin causes a variety of problems in cell-based research. In vivo, endotoxin may cause various side effects, including inflammatory response, organ failure or septic shock in host organisms. Presence of endotoxin in any of these has a detrimental effect on culturing of cells and can lead to generation of irreproducible or negative experimental data. Therefore, it is critical to remove endotoxin from samples and products. BioVision‘s ToxOut™ Rapid Endotoxin Removal Agarose can quickly and effectively eliminate endotoxins to < 0.05 EU/ml in solutions containing proteins or pharmacologically important components via the immobilized polymyxin B, which is known for capturing endotoxin and preventing toxic effects.

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