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Total D-Amino Acid Assay Kit (Fluorometric)

The first kit in the market that selectively measures total D-Amino Acids in biological samples
Catalog #: K445

In stock

$425.00

Product Details

Cat # +Size K445-100
Size 100 assays
Kit Summary • Detection method- Fluorescence (Ex/Em 535/587 nm)
• Species reactivity- Eukaryotes
• Specifically detect D-Amino Acids: Does not react or detect L-amino acids in biological samples
Detection Method Fluorescence (Ex/Em 535/587 nm)
Species Reactivity Eukaryotes
Applications • Measurement of total D-Amino acids concentrations in biological samples
• Analysis of relationship between D-Amino acids in physiological conditions including schizophrenia, Alzheimer disease, etc.
Features & Benefits • Simple procedure; takes ~ 2 hours
• Fast and convenient
• Kit contains the necessary reagents for accurate measurement of D-Amino Acid in biological samples
Kit Components • DAA Assay Buffer
• DAA Cofactor
• DAA Enzyme Mix
• DAA Developer Mix
• DAA Probe
• DAA Standard
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

D-Amino acids are present in both eukaryotes and prokaryotes. D-Amino acids act as a component of the cell wall in prokaryotes and a neurological regulator in eukaryotes. In mammals, D-Amino acids play an important role in physiological functions and their levels are regulated by D-Amino acid oxidase in the central nervous systems. Some important D-Amino acids include D-serine, D-aspartate and D-alanine. D-serine acts as a modulator of N-Methyl-D-aspartate receptor (NMDA receptor, NMDAR), while D-aspartate and D-alanine have been found to be elevated in the white and the gray matter respectively in patients’ brains suffering Alzheimer’s disease. The abnormal levels of D-Amino acids could be used as a marker of neurological diseases: total D-Amino acid concentration in cerebrospinal fluid (CSF) has been shown to be higher in patients with Alzheimer’s disease when compared to samples from healthy donors. BioVision’s Total D-Amino Acid Assay Kit (Fluorometric) provides a quick, specific and easy method for measuring total D-Amino acid concentrations in a wide variety of samples. In this assay, D-Amino acids are converted into an intermediate by the DAA enzyme mix that will further react with a probe to produce a strong fluorescence signal (Ex/Em= 535/587nm). The kit is simple to use, sensitive and high-throughput adaptable and can detect as low as 1.9 μM of D-Amino acids in biological samples.


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