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Torin 1

A potent mTOR inhibitor
Catalog #: 2273
SKU-Size Size Price Qty
2273-5 5 mg
2273-25 25 mg
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Product Details

Alternate Name 1-[4-[4-(1-Oxopropyl)-1-piperazinyl­]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benz­o[h]-1,6-naphthyridin-2(1H)-one
Appearance Slightly pinkish solid
CAS # 1222998-36-8
Molecular Formula C₃₅H₂₈F₃N₅O₂
Molecular Weight 607.62
Purity ≥98% by HPLC
Solubility DMSO (~2 mg/ml), N-methyl-2-pyrrolidone (~25 mg/ml)
InChi InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
PubChem CID 49836027
MDL Number MFCD18782653
Handling Protect from air and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent, selective and ATP-competitive mTOR inhibitor, with IC₅₀ values of 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 displays 1000-fold selectivity for mTOR over PI3K (EC₅₀ = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases.

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Benny Zhitomirsky, Lysosomotropic drugs activate TFEB via lysosomal membrane fluidization and consequent inhibition of mTORC1 activity. Cell Death Dis, Dec 2018; 30546014.
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