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Tolvaptan

a selective, A competitive arginine vasopressin V2 receptor antagonist
Catalog #: B2583
SKU-Size Size Price Qty
B2583-5 5 mg
$135.00
B2583-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name OPC-41061, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-benzamide, OPC 41061, OPC41061
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 150683-30-0
Molecular Formula C₂₆H₂₅ClN₂O₃
Molecular Weight 448.94
Purity ≥98%
Solubility >100 mg/ml in DMSO
SMILES CC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)C(=O)N3CCCC(C4=C3C=CC(=C4)Cl)O)C
InChi InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30) 22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
InChi Key GYHCTFXIZSNGJT-UHFFFAOYSA-N
PubChem CID 216237
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tolvaptan is a selective, competitive arginine vasopressin V2 receptor antagonist (IC₅₀ = 3 nM for rat receptor) and a diuretic agent. It is selective for V2 over V1 receptors (IC₅₀ = 0.58 μM). Used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).


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