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Toceranib

An ATP-competitive multi-targeted receptor tyrosine kinase inhibitor
Catalog #: B1542
SKU-Size Size Price Qty
B1542-5 5 mg
$145.00
B1542-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide; PHA 291639, SU 11654
Appearance Orange solid
CAS # 356068-94-5
Molecular Formula C₂₂H₂₅FN₄O₂
Molecular Weight 396.46
Purity ≥98% by HPLC
Solubility DMSO (~ 4 mg/ml)
SMILES CC1=C(NC(=C1C(=O)NCCN2CCCC2)C)C=C3C4=C(C=CC(=C4)F)NC3=O
InChi InChI=1S/C22H25FN4O2/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28)/b17-12-
InChi Key SRSGVKWWVXWSJT-ATVHPVEESA-N
PubChem CID 5329106
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Toceranib is a potent, cell-permeable, ATP-competitive multi-targeted receptor tyrosine kinase inhibitor that is structurally related to Sunitinib (Cat. No. 2097). It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit. Additionally, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death. It is active in vivo and is commonly used against solid tumors in dogs.


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