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TNF-alpha, rat recombinant

based on 4 citations in multiple journalsTNF-alpha, rat recombinant44.1 4
A potent cytokine exerting cytotoxic effects on a wide range of cells
Catalog #: 1052
SKU-Size Size Price Qty
1052-10 10 μg
1052-50 50 μg
1052-1000 1 mg
More Sizes Get Quote

Product Details

Alternate Name Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2
Gene Symbol TNFA
Gene ID 24835
Accession # P16599.1
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Sterile filtered and lyophilized from 1X PBS
Molecular Weight 17.0 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by the cytolysis of murine L929 cells in the presence of actinomycin D is < 0.05 ng/ml, corresponding to a specific activity of > 2 x 10⁷ units/mg.
Reconstitution Instructions We recommend a quick spin followed by reconstitution in H₂O to a concentration of 0.1 – 1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Tumor Necrosis Factor-α (TNF-α) is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. Rat TNF-α is a 17 kDa protein containing 157 amino acid residues.

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Muehlbauer, S. et al. Proteasome Inhibitors Prevent Caspase-1-Mediated Disease in Rodents Challenged with Anthrax Lethal Toxin. Am. J. Pathol., 2010; 177: 735-743.
Saito Y et al. (2007) Am J Physiol. Heart Circ. Physiol. 293: H3490-H3497.
Yang, Z. F. et al. (2004) J. Immunol. 173:2507-2515.
Yang, Z. F. et al. (2005) Int. Immunol. 17: 1391-1397.
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