Product Details
| abID | ab52126 |
|---|---|
| Alternate Name | Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2 |
| Gene Symbol | TNFA |
| Gene ID | 7124 |
| Accession # | P01375 |
| Source | E. coli. |
| Appearance | Lyophilized powder |
| Physical Form Description | Lyophilized in 50 mM Tris, 150 mM NaCl pH 8.5 |
| Molecular Weight | 17.4 kDa |
| Purity by SDS-PAGE | ≥98% |
| Purity by | ≥98% |
| Biological Activity | ED50 < 0.05 ng/ml as determined by the cytolysis of murine L929 cells in the presence of actinomycin D. |
| Reconstitution Instructions | Reconstitute in H₂O to a concentration of 1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Tumor Necrosis Factor-α(TNF-α) is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. Human TNF-α is a 17.4 kDa protein containing 157 amino acid residues.
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Hui et al., Individual Cytokines Modulate the Neurological Symptoms of ATMDeficiency in a Region Specific Manner. eNeuro, Jul 2015; 2: ENEURO.0032-15.2015
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B Activation. J. Virol., Jul 2014; 88: 7941 - 7951.Zhang et al., Herpes Simplex Virus 1 E3 Ubiquitin Ligase ICP0 Protein Inhibits Tumor Necrosis Factor Alpha-Induced NF-B Activation by Interacting with p65/RelA and p50/NF-
B1. J. Virol., Dec 2013; 87: 12935 - 12948.
B Activation by Interacting with p65/RelA and p50/NF-B1. J. Virol., Dec 2013; 87: 12935 - 12948.Zheng, Z. et. al. Enterovirus 71 2C Protein Inhibits TNF-α–Mediated Activation of NF-
B by Suppressing I
B Kinase β Phosphorylation. J. Immunol., Sep 2011; 187: 2202 - 2212.
B by Suppressing IB Kinase β Phosphorylation. J. Immunol., Sep 2011; 187: 2202 - 2212.Bhola, P, Simon, S. Determination and Divergence of Apoptosis Susceptibility in Mammalian Cells. J. Cell Sci. 2009; 122: 4296-4302.
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