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TNF-alpha, human recombinant

based on 6 citations in multiple journalsTNF-alpha, human recombinant64.1 4
A potent cytokine exerting cytotoxic effects on a wide range of cells
Catalog #: 1050
SKU-Size Size Price Qty
1050-10 10 μg
$90.00
1050-50 50 μg
$205.00
1050-1000 1 mg
$1,490.00
More Sizes Get Quote

Product Details

Alternate Name Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2
Gene Symbol TNFA
Gene ID 7124
Accession # P01375
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Lyophilized in 50 mM Tris, 150 mM NaCl pH 8.5
Molecular Weight 17.4 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Biological Activity ED50 < 0.05 ng/ml as determined by the cytolysis of murine L929 cells in the presence of actinomycin D.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Tumor Necrosis Factor-α(TNF-α) is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. Human TNF-α is a 17.4 kDa protein containing 157 amino acid residues.


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Hui et al., Individual Cytokines Modulate the Neurological Symptoms of ATMDeficiency in a Region Specific Manner. eNeuro, Jul 2015; 2: ENEURO.0032-15.2015
Wang et al., Herpes Simplex Virus 1 Protein Kinase US3 Hyperphosphorylates p65/RelA and Dampens NF-Description: {kappa}B Activation. J. Virol., Jul 2014; 88: 7941 - 7951.
Zhang et al., Herpes Simplex Virus 1 E3 Ubiquitin Ligase ICP0 Protein Inhibits Tumor Necrosis Factor Alpha-Induced NF-Description: {kappa}B Activation by Interacting with p65/RelA and p50/NF-Description: {kappa}B1. J. Virol., Dec 2013; 87: 12935 - 12948.
Zheng, Z. et. al. Enterovirus 71 2C Protein Inhibits TNF-α–Mediated Activation of NF-Description: {kappa}B by Suppressing IDescription: {kappa}B Kinase β Phosphorylation. J. Immunol., Sep 2011; 187: 2202 - 2212.
Bhola, P, Simon, S. Determination and Divergence of Apoptosis Susceptibility in Mammalian Cells. J. Cell Sci. 2009; 122: 4296-4302.
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