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Product Details
| Cat # +Size | P1596-10 |
|---|---|
| Size | 10 μg |
| Alternate Name | TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2. |
| Gene Symbol | TNF |
| Gene ID | 7124 |
| Accession # | P01375 |
| Source | E. coli |
| Appearance | Sterile Filtered colorless solution |
| Physical Form Description | In Phosphate buffer saline(pH7.4) and 10% glycerol. |
| Molecular Weight | 17.5kDa. |
| Purity by SDS-PAGE | >90% |
| Biological Activity | The ED50 Is < 15 ng/ml and is measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. |
| Amino Acid Sequence | aa 78-234 |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Tumor necrosis factor is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is involved in systemic inflammationand secreted mainly by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.
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