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TNF-alpha, Bovine Recombinant

A potent cytokine exerting cytotoxic effects on a wide range of cells
Catalog #: P1596
$345.00

Product Details

Cat # +Size P1596-10
Size 10 μg
Alternate Name TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Cachectin, DIF, TNFA, TNFSF2.
Gene Symbol TNF
Gene ID 7124
Accession # P01375
Source E. coli
Appearance Sterile Filtered colorless solution
Physical Form Description In Phosphate buffer saline(pH7.4) and 10% glycerol.
Molecular Weight 17.5kDa.
Purity by SDS-PAGE >90%
Biological Activity The ED50 Is < 15 ng/ml and is measured in a cytotoxicity assay using L929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D.
Amino Acid Sequence aa 78-234
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tumor necrosis factor is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is involved in systemic inflammationand secreted mainly by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.


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