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TLR5(Toll-like receptor 5) Polyclonal Antibody

Polyclonal Antibody to detect TLR5 in Human, Mouse, Rat samples
Catalog #: 3555
$295.00

Product Details

Cat # +Size 3555-100
Size 100 µg
Antibody Target TLR5(Toll-like receptor 5)
Host Rabbit
Antibody Type Polyclonal
Isotype rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 330 of human TLR5
Accession # O60602
Gene ID 7100
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 ml protein A purified rabbit anti-TLR5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 10% glycerol and 0.02% thimerosal.
Purification Affinity purified rabbit IgG
Species Reactivity Human, Mouse, Rat
Application Western blot
Application & Usage Western blot: 1-4 µg
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The Toll-like receptor (TLR) family of proteins are characterized by a highly conserved Toll homology(TH) domain,which is essential for Toll-induced signal transduction.TLR1,as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride(LPS) stimulation, which results in the activation and translocation of NFkB and suggests that these receptors are involved in mediating inflammatory responses. TLR6 is highly homologous to TLR1, and like other members of TLR family, it induces NFkB Signaling upon activation. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes.


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