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TLR4 / CD284, Human Recombinant

TLR family member which plays a fundamental role in pathogen recognition and activation of innate immunity
Catalog #: P1417
$295.00

Product Details

Cat # +Size P1417-50
Size 50 µg
Alternate Name ARMD10, CD284, TLR-4, TLR4, TOLL
Gene Symbol TLR4
Gene ID 7099
Accession # O00206
Source Insect Cells (sf9)
Appearance Sterile Filtered colorless solution
Physical Form Description Liquid
Molecular Weight 70.5 kDa (C terminal 6x His tag)
Purity by SDS-PAGE >95%
Amino Acid Sequence aa 24-631
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

TLR4 is a member of Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR4 receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.


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