Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

TLR4 / CD284, Human Recombinant

TLR family member which plays a fundamental role in pathogen recognition and activation of innate immunity
Catalog #: P1417

Product Details

Cat # +Size P1417-50
Size 50 µg
Alternate Name ARMD10, CD284, TLR-4, TLR4, TOLL
Gene Symbol TLR4
Gene ID 7099
Accession # O00206
Source Insect Cells (sf9)
Appearance Sterile Filtered colorless solution
Physical Form Description Liquid
Molecular Weight 70.5 kDa (C terminal 6x His tag)
Purity by SDS-PAGE >95%
Amino Acid Sequence aa 24-631
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


TLR4 is a member of Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR4 receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.