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A potent and selective VEGFR inhibitor
Catalog #: B1545
SKU-Size Size Price Qty
B1545-5 5 mg
B1545-25 25 mg
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Product Details

Alternate Name 1-(2-chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-3-(5-methylisoxazol-3-yl)urea; AV 951; KRN951
Appearance Crystalline solid
CAS # 475108-18-0 
Molecular Formula C₂₂H₁₉ClN₄O₅ 
Molecular Weight 454.86
Purity ≥98% by HPLC
Solubility DMSO ( 10 mg/ml)
InChi InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
PubChem CID 9911830
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Tivozanib (AV-951) is a potent and selective VEGFR inhibitor with IC₅₀ values of of 30, 6.5 15 nM, for VEGFR-1, VEGFR-2, and VEGFR-3, respectively. It also inhibits PDGFR and c-Kit, with lower activity observed against FGFR-1, Flt3, c-Met,EGFR and IGF-1R.

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