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Tivantinib

A potent, cell-permeable inhibitor of c-Met with potential antineoplastic activity.
Catalog #: B1546
SKU-Size Size Price Qty
B1546-5 5 mg
$85.00
B1546-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione; ARQ197
Appearance Crystalline solid
CAS # 905854-02-6
Molecular Formula C₂₃H₁₉N₃O₂ 
Molecular Weight 369.41
Purity ≥98% by HPLC
Solubility DMSO (~20 mg/ml)
SMILES C1CC2=CC=CC3=C2N(C1)C=C3C4C(C(=O)NC4=O)C5=CNC6=CC=CC=C65
InChi InChI=1S/C23H19N3O2/c27-22-19(16-11-24-18-9-2-1-7-14(16)18)20(23(28)25-22)17-12-26-10-4-6-13-5-3-8-15(17)21(13)26/h1-3,5,7-9,11-12,19-20,24H,4,6,10H2,(H,25,27,28)/t19-,20-/m0/s1
InChi Key UCEQXRCJXIVODC-PMACEKPBSA-N
PubChem CID 11494412
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tivantinib (ARQ-197) is a potent, cell-permeable inhibitor of c-Met with potential antineoplastic activity. Tivantinib binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein.


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