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Tirabrutinib hydrochloride

A potent Bruton's Tyrosine Kinase (BTK) inhibitor
Catalog #: B2556
SKU-Size Size Price Qty
B2556-5 5 mg
B2556-25 25 mg
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Product Details

Alternate Name GS4059, ONO-WG-307, GS 4059, GS-4059, ONO-4059, ONO4059 HCl, (R)-6-amino-9-(1-(but-2-ynoyl)pyrrolidin-3-yl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 1439901-97-9
Molecular Formula C₂₅H₂₃ClN₆O₃
Molecular Weight 490.95
Purity ≥98% by HPLC
Solubility in DMSO
InChi InChI=1S/C25H22N6O3.ClH/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17) 34-19-7-4-3-5-8-19;/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28);1H/t18-;/m1./s1
PubChem CID 71571562
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Tirabrutinib (ONO-4059) hydrochloride is a potent and selective BTK (Bruton’s Tyrosine Kinase) inhibitor (IC₅₀ = 2.2 nm). Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

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