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TIP60 Antibody

Polyclonal antibody to detect TIP60 (a HAT) in Human, Chimpanzee, Orangutan, Equine, Canine, Mouse, Bovine, Rat, Opossum, Zebrafish and Xenopus samples
Catalog #: 6126
$225.00

Product Details

Cat # +Size 6126-50
Size 50 μg
Antibody Target TIP60
Alternate Name Lysine Acetyltransferase 5; KAT5
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide within the region of human TIP60 amino acids 480-530.
Accession # Q92993
Gene ID 10524
Appearance Colorless liquid
Formulation 50 µg of antibody in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Purification Protein A purified
Species Reactivity Human, chimpanzee, orangutan, equine, canine, mouse, bovine, rat, opossum, zebrafish, xenopus
Application Western blot, Immunohistochemistry
Positive Control Western blot: Human brain lysate, mouse brain lysate, rat brain lysate
Application & Usage Western blot: 0.25-1.0 µg/ml, IHC (paraffin embedded sections): 5 µg/ml. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

TIP60, originally isolated as an HIV-1 TAT-interactive protein, is known to interact with the viral TAT protein that leads to HTATIP polyubiquitination and targets it for degradation. It belongs to the MYST family of histone acetyltransferases (HATs). TIP60 is a catalytic subunit of the NuA4 HAT complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. A co-regulator of transcription factors, TIP60 either promotes or suppresses tumorigenesis. TIP60 is an enzyme that has a role in DNA repair and apoptosis and is thoμght to play an important role in signal transduction.


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