Product Details
| Alternate Name | Gabitril; (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid;hydrochloride; (r)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride; (3R)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic acid hydrochloride |
|---|---|
| Appearance | White to Beige Powder |
| CAS # | 145821-59-6 |
| Molecular Formula | C₂₀H₂₆ClNO₂S₂ |
| Molecular Weight | 412.01 |
| Purity | ≥ 98% |
| Solubility | ~20 mg/ml in DMSO, ~10 mg/ml in water |
| SMILES | CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C.Cl |
| InChi | InChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1 |
| InChi Key | YUKARLAABCGMCN-PKLMIRHRSA-N |
| PubChem CID | 91274 |
| MDL Number | MFCD07369025 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Tiagabine is a selective inhibitor of GABA transporter 1 (GAT-1) and a GABA uptake inhibitor. It shows an IC₅₀ of 49 nM for GAT-1 expressed in CHO cells. It reduces allodynia in a rodent model of neuropathic pain at a dose of 72.8 µmol/kg, ip. It shows anticonvulsant effects and is used in the treatment of epilepsy.
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