Tiagabine hydrochloride

A selective inhibitor of GAT-1
Catalog #: B3114 | abID:

Product Details

Alternate Name Gabitril; (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid;hydrochloride; (r)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride; (3R)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic acid hydrochloride
Appearance White to Beige Powder
CAS # 145821-59-6
Molecular Formula C₂₀H₂₆ClNO₂S₂
Molecular Weight 412.01
Purity ≥ 98%
Solubility ~20 mg/ml in DMSO, ~10 mg/ml in water
SMILES CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C.Cl
InChi InChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1
InChi Key YUKARLAABCGMCN-PKLMIRHRSA-N
PubChem CID 91274
MDL Number MFCD07369025
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tiagabine is a selective inhibitor of GABA transporter 1 (GAT-1) and a GABA uptake inhibitor. It shows an IC₅₀ of 49 nM for GAT-1 expressed in CHO cells. It reduces allodynia in a rodent model of neuropathic pain at a dose of 72.8 µmol/kg, ip. It shows anticonvulsant effects and is used in the treatment of epilepsy.


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