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THZ1 (Free base)

A potent CDK7 inhibitor
Catalog #: 9664
SKU-Size Size Price Qty
9664-5 5 mg
$225.00
9664-25 25 mg
$895.00
More Sizes Get Quote

Product Details

Alternate Name (E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
Appearance Off-white solid
CAS # 1604810-83-4
Molecular Formula C₃₁H₂₈ClN₇O₂
Molecular Weight 566.05
Purity ≥95% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES CN(C)CC=CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl
InChi InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+
InChi Key OBJNFLYHUXWUPF-IZZDOVSWSA-N
PubChem CID 73602827
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

THZ1 is a potent, cell-permeable, and selective covalent CDK7 inhibitor (IC₅₀ = 3.2 nM) that preferentially diminishes transcription in cancer cells. It displays unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.


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