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Thy1/CD90 Antibody (NT)

Polyclonal Antibody to detect Thy1/CD90 in human samples.
Catalog #: 6778
$245.00

Product Details

Cat # +Size 6778-100
Size 100 μl
Antibody Target Thy1/CD90
Alternate Name THY1; Thy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD90
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This THY1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-65 amino acids from the N-terminal region of human THY1.
Accession # 7070
Gene ID P04216
Appearance Colorless liquid
Formulation In PBS with 0.09% (W/V) sodium azide.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Species Reactivity Human, Rat.
Application Western blot, IHC.
Positive Control Western blot: T47D, HL60 cell lysate, IHC: human hepatocarcinoma and cancer tissue .
Application & Usage WB: 1:1000, IHC: 1:50 – 1:100.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Thy1 is a GPI-anchored, developmentally regulated protein involved in various signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosis. It is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migratory events, such as neurite extension. Decreased Thy1 expression is associated with the development of epithelial ovarian cancer, revealing its role as a putative tumor suppressor gene of human ovarian cancer. Thy1 knockout mice have impaired cutaneous immune responses and abnormal retinal development. Thy1 is epigenetically regulated or deregulated in some disease states, such as pulmonary fibrosis. The potentially reversible hypermethylation of the Thy1 promoter offers the possibility of novel therapeutic options in this disease.


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