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Thrombin, Active, Bovine Plasma (High Activity)

A coagulation protein and a serine protease.
Catalog #: 7592
SKU-Size Size Price Qty
7592-1 1 KU
$100.00
7592-10 10 KU
$405.00
7592-100 100 KU
$890.00
More Sizes Get Quote

Product Details

Alternate Name Activated Factor IIa
Gene Symbol F2
Gene ID 280685
Accession # P00735
Source Bovine plasma
Appearance Lyophilized
Physical Form Description Sterile filtered and lyophilized with Mannitol and Sodium Chloride.
Molecular Weight 37 kDa
Purity by SDS-PAGE ≥98%
Biological Activity >1500 units/mg powder.
Reconstitution Instructions Reconstitute in sterile water (100 U/ml) with 0.9% NaCl. It forms a clear solution.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.


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