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Thioredoxin 1 Antibody (3A1)

Monoclonal Antibody to detect thioredoxin I in human samples.
Catalog #: 6166
$325.00

Product Details

Cat # +Size 6166-100
Size 100 μl
Antibody Target Thioredoxin 1
Alternate Name TXN, TRX, TRX1.
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG 1
Immunogen Recombinant human protein purified from E.coli
Accession # O43396
Gene ID 9352
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 100 µl of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol
Purification Protein G purified Antibody
Species Reactivity Human
Application Western blot,IP, ELISA.
Positive Control WB analysis of cell lysates.
Application & Usage Western blot: 1:1000, IP: 1-2 µl, ELISA.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The mammalian thioredoxin reductases (TrxRs) are a family of seleno-cysteine containing pyridine nucleotide-disulfide oxido-reductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate seleno-cysteine (SeCys) residue in the conserved sequence(-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55 – 58 kDa in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various biological phenomena. TrxR1 plays a central role as a glucosyl donor in cellular metabolic pathways.


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