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Thiazovivin

A hESC survival agent
Catalog #: 1681
SKU-Size Size Price Qty
1681-1 1 mg
$140.00
1681-5 5 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide; Tzv
Appearance Off-white solid
CAS # 1226056-71-8
Molecular Formula C₁₅H₁₃N₅OS
Molecular Weight 311.36
Purity ≥98% by HPLC
Solubility DMSO (100 mM)
SMILES C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3
InChi InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
InChi Key DOBKQCZBPPCLEG-UHFFFAOYSA-N
PubChem CID 46209426
MDL Number MFCD16495823
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. Helps in promoting human embryonic stem cell (hESC) survival by > 30-fold. Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB-431542 (Cat. No. 1674) and PD 0325901 (Cat. No.1643).Acts as a Rho-associated Kinase (ROCK) inhibitor. Tzv (2 µM) inhibits ROCK activity and protect hESCs at a similar level as Y-27632 (10 µM) (Cat. No. 1596), a well-known, selective ROCK inhibitor.


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