Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]


A potent and selective EGFR inhibitor
Catalog #: B3004
SKU-Size Size Price Qty
B3004-1 1 mg
B3004-5 5 mg
More Sizes Get Quote

Product Details

Alternate Name HMPL-309; (3aR,6aR)-N-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]-1-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrole-5-carboxamide
Appearance Solid
CAS # 1353644-70-8
Molecular Formula C₂₅H₂₆N₆O₂
Molecular Weight 442.5
Purity >98%
Solubility ~5 mg/ml in DMSO. May need ultrasonication.
InChi InChI=1S/C25H26N6O2/c1-4-16-6-5-7-18(10-16)28-24-19-11-21(23(33-3)12-20(19)26-15-27-24)29-25(32)31-13-17-8-9-30(2)22(17)14-31/h1,5-7,10-12,15,17,22H,8-9,13-14H2,2-3H3,(H,29,32)(H,26,27,28)/t17-,22+/m1/s1
PubChem CID 54759275
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Theliatinib is a potent epidermal growth factor receptor EGFR tyrosine kinase inhibitor with a Ki value of 0.05 nM and IC₅₀ of 3 nM. It exhibits strong antitumor activity in patient-derived estrogen cancer xenograft (PDECX) models with high EGFR expression, including remarkable tumor regression in two PDECX models with both EGFR gene amplification and protein overexpression in a dose-dependent manner (5 and 15 mg/kg/day). The efficacy of theliatinib is reduced in the models with PI3KCA mutations or FGFR1 overexpression in addition to high EGFR expression.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.