A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis

WARNING: This product can expose you to chemicals including Thalidomide, which is [are] known to the State of California to cause birth defects or other reproductive harm.  For more information go to  www.P65Warnings.ca.gov.
Catalog #: 2020 | abID:

Product Details

Alternate Name (RS)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
Appearance White solid
CAS # 50-35-1
Molecular Formula C₁₃H₁₀N₂O₄
Molecular Weight 258.23
Purity ≥98% by TLC
Solubility DMSO (5 mg/ml)
InChi InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
PubChem CID 5426
MDL Number MFCD00153873
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A teratogen and sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Thalidomide initiates its teratogenic effects by binding to cereblon (CRBN), a thalidomide-binding protein, and inhibiting the associated ubiquitin ligase activity.

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