Product Details
| Alternate Name | (RS)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione |
|---|---|
| Appearance | White solid |
| CAS # | 50-35-1 |
| Molecular Formula | C₁₃H₁₀N₂O₄ |
| Molecular Weight | 258.23 |
| Purity | ≥98% by TLC |
| Solubility | DMSO (5 mg/ml) |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O |
| InChi | InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17) |
| InChi Key | UEJJHQNACJXSKW-UHFFFAOYSA-N |
| PubChem CID | 5426 |
| MDL Number | MFCD00153873 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A teratogen and sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Thalidomide initiates its teratogenic effects by binding to cereblon (CRBN), a thalidomide-binding protein, and inhibiting the associated ubiquitin ligase activity.
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