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(±)-Thalidomide

A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis
Catalog #: 2020
SKU-Size Size Price Qty
2020-10 10 mg
$70.00
2020-50 50 mg
$236.00
More Sizes Get Quote

Product Details

Alternate Name (RS)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
Appearance White solid
CAS # 50-35-1
Molecular Formula C₁₃H₁₀N₂O₄
Molecular Weight 258.23
Purity ≥98% by TLC
Solubility DMSO (5 mg/ml)
SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O
InChi InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
InChi Key UEJJHQNACJXSKW-UHFFFAOYSA-N
PubChem CID 5426
MDL Number MFCD00153873
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A teratogen and sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Thalidomide initiates its teratogenic effects by binding to cereblon (CRBN), a thalidomide-binding protein, and inhibiting the associated ubiquitin ligase activity.


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