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TGN-020

An aquaporin 4 inhibitor
Catalog #: B2979
SKU-Size Size Price Qty
B2979-5 5 mg
$60.00
B2979-25 25 mg
$240.00
More Sizes Get Quote

Product Details

Alternate Name N-(1,3,4-thiadiazol-2-yl)pyridine-3-carboxamide; n-(1,3,4-thiadiazol-2-yl)nicotinamide; 2-(Nicotinamido)-1,3,4-thiadiazole
Appearance Off White Solid
CAS # 51987-99-6
Molecular Formula C₈H₆N₄OS
Molecular Weight 206.22
Purity 98%
Solubility ~4 mg/ml in DMSO
SMILES C1=CC(=CN=C1)C(=O)NC2=NN=CS2
InChi InChI=1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)
InChi Key AGEGZHOPKZFKBP-UHFFFAOYSA-N
PubChem CID 4173511
MDL Number MFCD00708771
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

TGN-020 is an inhibitor of aquaporin 4 (AQP4), the most abundant water channel in brain. It inhibits AQP4 inhibitor with an IC₅₀ of 3 μM in vitro. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduces ischemic cerebral edema associated with focal cerebral ischemia in a mouse model.


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