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TGF-beta1, human recombinant

based on 8 citations in multiple journalsTGF-beta1, human recombinant84.1 4
A protein that controls proliferation, cellular differentiation, & other functions in most cells
Catalog #: 4342
SKU-Size Size Price Qty
4342-5 5 μg
$290.00
4342-50 50 μg
$1,650.00
4342-500 500 μg
$7,950.00
More Sizes Get Quote

Product Details

Alternate Name Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factor
Gene Symbol TGFB1
Gene ID 7040
Accession # P01137
Source CHO cells
Appearance Lyophilized protein
Physical Form Description Lyophilized from Sodium Citrate, pH3.5 buffer
Molecular Weight 25.0 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by the ability of TGF-β1 to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is <0.05 ng/ml, corresponding to a specific activity of >2 x 10⁷ units/mg.
Reconstitution Instructions Reconstitution in H₂O to a concentration of 50 ug/ml (e.g., 5 ug/100 μl) will yield a solution of 1 mM citrate buffer (pH 3.5). The solution can then be stored at 4°C for 1 month. It is recommended that further dilutions be made in PBS containing 2 mg/ml
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

TGF-β1 (Transforming Growth Factor-β1) is a member of the superfamily of homologous, disulfide-linked, homodimeric proteins that regulate the proliferation and differentiation of normal and transformed cells. Human TGF-β1 is a 25.0 kDa protein containing two identical 112 amino acid polypeptide chains linked by a single disulfide bond.


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Huijts et al., mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT (iNKT) Cells into Immunosuppressive Regulatory iNKT Cells. J. Immunol., Sep 2015; 195: 2038 - 2045.
Krista Ouwehand, et. al. Technical Advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration. J. Leukoc. Biol., Nov 2011; 90: 1027 - 1033.
Ursula Mayrhauser, et. al. Cell to Cell Interactions Influence Sensitivity of Liver Cell Lines during Hyperthermia. Anticancer Res, Nov 2011; 31: 3713 - 3717.
MAYRHAUSER, U. et. al. Effect of Hyperthermia on Liver Cell Lines: Important Findings for Thermal Therapy in Hepatocellular Carcinoma. Anticancer Res, May 2011; 31: 1583 - 1588.
Santegoets SJAM ET AL (2-8) j. Immunol. 180: 4540 - 4549.
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