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Product Details
| Alternate Name | N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide; SAR302503 |
|---|---|
| Appearance | White solid |
| CAS # | 936091-26-8 |
| Molecular Formula | C₂₇H₃₆N₆O₃S |
| Molecular Weight | 524.68 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~100 mg/ml) or Ethanol (~ 20 mg/ml) |
| SMILES | CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4 |
| InChi | InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) |
| InChi Key | JOOXLOJCABQBSG-UHFFFAOYSA-N |
| PubChem CID | 16722836 |
| MDL Number | MFCD09038564 |
| Handling | Protect from air and light |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
TG101348 is a potent, and selective inhibitor of JAK2 (IC₅₀ = 3 nM). It has a 35- and 334-fold selectivity over JAK3 and JAK1, respectively.
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