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TFF-2, human recombinant

A protein which protects and stabilizes the gastric mucus layer
Catalog #: 4745
SKU-Size Size Price Qty
4745-20 20 μg
$200.00
4745-100 100 μg
$625.00
4745-1000 1 mg
$2,940.00
More Sizes Get Quote

Product Details

Alternate Name Trefoil Factor 2, Spasmolytic polypeptide (SP), Spasmolysin
Gene Symbol TFF2
Gene ID 7032
Accession # Q03404
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives
Molecular Weight 12.0 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 µg/ml.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1-1.0 μg/μl. The solution can then be diluted into other aqueous buffers
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion. Recent data suggests a potential role for TFF2 in acute and chronic asthma. Recombinant human TFF2 is a 12.0 kDa polypeptide of 106 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.


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