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Terbinafine hydrochloride

A broad-spectrum antifungal agent
Catalog #: B2657
SKU-Size Size Price Qty
B2657-50 50 mg
$65.00
B2657-250 250 mg
$145.00
More Sizes Get Quote

Product Details

Alternate Name N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine, monohydrochloride
Appearance White solid
CAS # 78628-80-5
Molecular Formula C₂₁H₂₅N.HCl
Molecular Weight 327.89
Purity ≥98%
Solubility >30 mg/ml DMSO
SMILES CC(C)(C)C#CC=CCN(C)CC1=CC=CC2=CC=CC=C21.Cl
InChi InChI=1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;
InChi Key BWMISRWJRUSYEX-SZKNIZGXSA-N
PubChem CID 5282481
MDL Number MFCD00145430
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Terbinafine hydrochloride is a selective TASK3 (TWIK-related acid-sensitive K⁺ channel 3, KCNK9, K2P9.1) activator (pEC₅₀ = 6.2). It displays >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC₅₀ = 5.69). Also acts as a broad-spectrum antifungal agent; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.


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