A SirT2 inhibitor and a p53 activator
Catalog #: B2818 | abID:

Product Details

Alternate Name 4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide, 4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)phenylcarbamothioyl)benzamide, Benzamide, N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-
Appearance Crystalline solid
CAS # 1011557-82-6
Molecular Formula C₂₅H₃₄N₄O₂S
Molecular Weight 454.63
Purity ≥95%
Solubility ~20 mg/ml in DMSO
~1mg/ml in Ethanol
InChi InChI=1S/C25H34N4O2S/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32)
PubChem CID 24772043
MDL Number MFCD11976906
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Tenovin-6 is a SirT2 inhibitor and a p53 activator. It is a water-soluble analog of Tenovin-1. Tenovins inhibit the protein-deacetylase activities of SirT1 and SirT2. The IC₅₀ for inhibiting human SirT1 and SirT2 peptide deacetylase activity is 21 μM and 10 μM respectively. Tenovin-6 potently inhibits the proliferation of diffuse large B-cell lymphoma (DLBCL) and acute lymphoblastic leukemia cells.

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