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An allosteric inhibitor at YAP-TEAD protein-protein interaction
Catalog #: B3247
SKU-Size Size Price Qty
B3247-5 5 mg
B3247-25 25 mg
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Product Details

Alternate Name TEC347; 2-Chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)phenyl)ethan-1-one
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 2378626-29-8
Molecular Formula C₁₅H₁₁ClF₃NO
Molecular Weight 313.70
Purity ≥98% by HPLC
Solubility >50 mg/ml DMSO
InChi InChI=1S/C15H11ClF3NO/c16-9-14(21)12-6-1-2-7-13(12)20-11-5-3-4-10(8-11)15(17,18)19/h1-8,20H,9H2
PubChem CID 137796964
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and displays antitumor activity.

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