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A potent GSK3β inhibitor
Catalog #: 2854
SKU-Size Size Price Qty
2854-5 5 mg
2854-25 25 mg
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Product Details

Alternate Name 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Appearance White solid
CAS # 327036-89-5
Molecular Formula C₁₀H₁₀N₂O₂S
Molecular Weight 222.26
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
InChi InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
PubChem CID 4124851
MDL Number MFCD04973552
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


TDZD-8 is a non-ATP competitive inhibitor of the serine/threonine kinase glycogen synthase kinase 3β (GSK3β; IC₅₀ = 2 µM), binding to the active site of GSK3β. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase, or protein kinase C (IC₅₀s = >100 µM). TDZD-8 also causes rapid death of leukemia stem and progenitor cells.

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