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TDRD12-BD2 (908-999 aa) (His-Tagged), human recombinant

Involved in RISC complex and interaction with AEG-1 oncogene
Catalog #: 7254
SKU-Size Size Price Qty
7254-20 20 μg
$195.00
7254-100 100 μg
$595.00
7254-1000 1 mg
$4,850.00
More Sizes Get Quote

Product Details

Alternate Name ECAT8
Gene Symbol TDRD12
Gene ID 91646
Accession # Q587J7
Source E. coli
Appearance Liquid
Physical Form Description rh-TDRD12-BD2 is supplied as a solution in PBS Buffer containing 10% glycerol
Molecular Weight 13 kDa
Purity by SDS-PAGE ≥98%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Tudor domains are small protein structural motifs of about ~50 amino acids related to the “royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification, and chromatin remodeling. The tudor domains recognize symmetric methylated arginine or methylated lysine residues. Tudor domain proteins act as an oncogene and play a very important role in HCC and colon cancer. TDRD is also involved in RISC complex and interacts with AEG-1 oncogene. The tudor domain can bind to methylated arginine protein and promote tumor angiogenesis in human hepatocellular carcinoma, etc. The recombinant protein includes TDRD12 (domain 908-999aa) with N-terminal His-tag.


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