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TDP1 Antibody (Clone AT1F2)

Monoclonal Antibody to detect TDP1 in human samples
Catalog #: 6698
$315.00

Product Details

Cat # +Size 6698-50
Size 50 μg
Antibody Target TDP1
Alternate Name Tyrosyl-DNA phosphodiesterase 1, TDP1 protein, TDP1.
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1k
Immunogen Recombinant human TDP1 (1-298aa) purified from E. Coli. Anti-human TDP1 mAb, clone AT1F2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TDP1 protein.
Accession # Q9NUW8
Gene ID 55775
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation Supplied in PBS with 0.1% sodium azide.
Purification Protein-G affinity purified
Species Reactivity Human
Application Western Blot, ELISA
Positive Control Western blot: MCF7 Cell lysate
Application & Usage Western blot: ~1:1000 - 2000, ELISA.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tyrosyl-DNA phosphodiesterase (TDP1) is a DNA repair enzyme that catalyzes the hydrolysis of a phophodiester bond between a tyrosine residue and a DNA 3' phosphate. This protein is a member of the phospholipase D (PLD) superfamily and contains two PLD phosphodiesterase domains. Mutations in TDP1 are associated with the disease spino-cerebellar ataxia with axonal neuropathy (SCAN1) by interfering with DNA transcription or by inducting apoptosis in postmitotic neurons.


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