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A cereblon ligand for PROTACs
Catalog #: B2599
SKU-Size Size Price Qty
B2599-5 5 mg
B2599-25 25 mg
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Product Details

Alternate Name 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid, Carboxylic acid-functionalized Thalidomide, cereblon ligand for PROTACs
Peptide Sequence N/A
Appearance Off-white solid
CAS # 1061605-21-7
Molecular Formula C₁₅H₁₂N₂O₇
Molecular Weight 332.26
Purity ≥98% by HPLC
Solubility >30 mg/ml in DMSO
InChi InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)
PubChem CID 25015436
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


TCE35031 is an analog of Thalidomide (Cat. No. 2020) commonly used as a precursor to PROTACs (proteolysis-targeting chimera technologies) that hijack cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.

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