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Tazarotene

A selective retinoic acid receptor (RAR) agonist
Catalog #: B1812

In stock

SKU-Size Size Price Qty
B1812-5 5 mg
$115.00
B1812-25 25 mg
$455.00

Product Details

Alternate Name 6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester
Appearance Pale yellow solid
CAS # 118292-40-3
Molecular Formula C₂₁H₂₁NO₂S
Molecular Weight 351.46
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml) or EtOH (>15 mg/ml)
SMILES CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C
InChi InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3
InChi Key OGQICQVSFDPSEI-UHFFFAOYSA-N
PubChem CID 5381
MDL Number MFCD00867628
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tazarotene is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis, acne vulgaris and photoaging. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation.


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