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Anti-Tau-13 Antibody

Mouse monoclonal antibody that detects expression of Tau in human samples
Catalog #: 3453
$360.00

Product Details

Cat # +Size 3453-100
Size 100 µl
Antibody Target Tau
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG1
Immunogen Synthetic peptide corresponding to aa 15-25 on the longest isoform of human Tau
Accession # P10636
Gene ID 4137
Appearance Colorless liquid
Concentration Since the product is supplied as undiluted mouse ascites fluid, the concentration will vary from lot-to-lot. Concentration could be between 1-3 mg/ml
Formulation 100 µl undiluted mouse ascites fluid
Purification Affinity purified
Species Reactivity Human
Application Western Blotting
Application & Usage WB (1:500 - 1:1000). However, the optimal concentrations should be determined individually. The antibody recognizes 45-60 kDa human Tau. It does not react with murine, rat and bovine Tau
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thoμght to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer’s disease.


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What is Tau-13? Is Tau-13 an isoform of Tau?
Tau-13 is not an isoform of Tau. It is simply the name, number assigned to the clone for internal verification purposes and is not in any way relevant to any sort of biological function. Preliminary assignment of Anti Tau-13 epitope indicates that it maps to amino acid residues 15-25 on the longest isoform of human Tau.
What is the concentration of the antibody?
This antibody is provided as ascites. So, we are not able to measure the exact concentration. We estimate that the antibody provided is anywhere from 1-3 mg/mL.